Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
user
  1. Dashboard
  2. My Profile
  3. My Address
  4. My Orders
  5. Acro Membership
Login Register
Promotion
Recombinant Proteins ClearClear history
Recombinant Proteins CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP Cytokines Hot |Streptavidin（SA） Hot |Claudin 18.2 |Cadherin-17 
0
There is no goods in the shopping cart !
My Cart|Secure Checkout
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Activin RIB

Activin RIB

Brief Information

Name:Transforming growth factor beta receptor 1
Target Synonym:EC 2.7.11,TGF-beta type I receptor,Serine/threonine-protein kinase receptor R4,TGFBR1,Activin A receptor type II-like protein kinase of 53kD,Transforming Growth Factor Beta Receptor 1,Transforming Growth Factor-Beta Receptor Type I,Activin A Receptor Type II-Like Kinase, 53kDa,Activin Receptor-Like Kinase 5,TGFR-1,ALK-5,ALK5,SKR4,Mutant Transforming Growth Factor Beta Receptor I,TGF-Beta Receptor Type-1,TGF-Beta Receptor Type I,EC 2.7.11.30,ACVRLK4,LDS1A,LDS2A,AAT5,LDS1,TBRI,ESS1,MSSE,TbetaR-I,T
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

Product> Filter Results
By Product Status:
By Product Category:
By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
ACB-H52H4 Human Human Activin RIB / ACVR1B Protein, His Tag
ACB-H52H4-structure
ACB-H52H4-sds
ACRO Quality

Part of Bioactivity data

ACB-H52H4-SPR
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human TDGF1, Fc Tag on Protein A Biosensor, can bind Human Activin RIB, His Tag (Cat. No. ACB-H52H4) with an affinity constant of 5.6 μM as determined in BLI assay (ForteBio Octet Red96e) (QC Tested).

Protocol

Synonym Name

ACVR1b,ALK4,ACVRLK4,ACTR-IB,SKR2

Background

Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.

Clinical and Translational Updates

Related Molecule

Activin A

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Galunisertib LY-2157299 Phase 2 Clinical Eli Lilly And Company Breast Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Glioma; Peritoneal Neoplasms; Colorectal Neoplasms; Nasopharyngeal Carcinoma; Prostatic Neoplasms; Solid tumours; Neoplasms; Myelodysplastic Syndromes; Glioblastoma; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Carcinoma, Renal Cell; Rectal Neoplasms; Liver Neoplasms Details
GF-101 GFH-018; GF-101; GFH018 Phase 2 Clinical Genfleet Therapeutics (Shanghai) Inc Solid tumours; Liver Neoplasms; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Carcinoma, Non-Small-Cell Lung Details
ORG-129 ORG-129; AGMB-129 Phase 2 Clinical Origo Biopharma Sociedad Litmitada Crohn Disease Details
TRK-250 TRK-250; BNC-1021 Phase 1 Clinical Bonac Corp Idiopathic Pulmonary Fibrosis Details
Itacnosertib TP-0184 Phase 1 Clinical Tolero Pharmaceuticals Inc, Sumitomo Dainippon Solid tumours; Anemia Details
Oxinseti SH-3051 Phase 1 Clinical Nanjing Sanhome Pharmaceutical Co Ltd Solid tumours; Liver Neoplasms Details
AGMB-447 AGMB-447; ORG-447 Phase 1 Clinical AgomAb Therapeutics NV Idiopathic Pulmonary Fibrosis Details
TD-1058 Phase 1 Clinical Theravance Biopharma Inc Idiopathic Pulmonary Fibrosis Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Email
Email
order@acrobiosystems.com
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA
linkedin twitter facebook youtube

Leave a message

Copyright © 2017 ACROBiosystems. All Rights Reserved
|Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap